JPEG artifacts occur as a result of saving an image in the JPEG format. The compressed artifacts differ from regular ISO noise because they are caused by different processes involved with generating an image. 

A noise reduction tool would not be effective at removing JPEG artifacts without a heavy loss of detail. And while Topaz DeJPEG offers some noise suppression features, they are not as powerful as the specialized functionality available in Topaz DeNoise. 

An image that has strong JPEG artifacting will have the best results with Topaz DeJPEG, while an image with regular ISO noise experiences the best results with Topaz DeNoise.
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